rs114198947 - KRT8

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes - Unknown journal (n.d.) · Unknown authors · PubMed 34124712

  ABSTRACT: Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability, few genetic risk loci have been identified for either opioid or cocaine dependence (OD or CD, respectively). A genome-wide association study of OD and CD related phenotypes reflecting the time between first self-reported use of these substances and a first DSM-IV dependence diagnosis was conducted. Methods: Cox proportional hazards regression in a discovery sample of 6,188 African-Americans (AAs) and 6,835 European-Americans (EAs) participants in a genetic study of multiple substance dependence phenotypes were used to test for association between genetic variant

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