Expressive

rs114194742 - ZBTB42 - VESTAR

Magnitude 4.5 · 1 study on file

Reported associations

  • GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals - Unknown journal (n.d.) · Unknown authors · PubMed 29213071

    ABSTRACT: QT interval prolongation is a heritable risk factor for ventricular arrhythmias and can predispose to sudden death. Most genome-wide association studies (GWAS) of QT were performed in European ancestral populations, leaving other groups uncharacterized. Herein we present the first QT GWAS of Hispanic/Latinos using data on 15,997 participants from four studies. Study-specific summary results of the association between 1000 Genomes Project (1000G) imputed SNPs and electrocardiographically measured QT were combined using fixed-effects meta-analysis. We identified 41 genome-wide significant SNPs that mapped to 13 previously identified QT loci. Conditional analyses distinguished six secondary signals at NOS1AP (n = 2), ATP1B1 (n = 2), SCN5A (n = 1), and KCNQ1 (n = 1).

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Serum electrolytes - potassium, magnesium, calcium Moderate

    QT interval duration depends directly on serum K+, Mg2+, Ca2+ levels; electrolyte imbalance worsens QT prolongation

    Baseline serum electrolytes; monitor annually or if symptoms develop

Discuss with your doctor

  • QT prolongation risk assessment with cardiologist Moderate

    ZBTB42 variant significantly prolongs QT interval; cardiologist should evaluate absolute arrhythmia risk

    Schedule cardiology consultation to assess QT prolongation and discuss management

Drug interactions

  • QT-prolonging medications Moderate

    Medications that prolong QT interval have additive effects with genetic QT prolongation

    Discuss medication review with doctor to avoid QT-prolonging drugs

Screening

  • ECG screening for QT interval Moderate

    ZBTB42 rs114194742 T allele prolongs QT interval by 14.5ms, increasing torsades de pointes risk

    Baseline ECG with QTc measurement; consider repeat every 1-2 years