Expressive

rs114190122 - CLSTN1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma. - Toxicological sciences : an official journal of the Society of Toxicology (2016) · Yucesoy B, Kaufman KM, Lummus ZL, Weirauch MT, Zhang G, Cartier A, Boulet LP, Sastre J, Quirce S, Tarlo SM, Cruz MJ, Munoz X, Harley JB, Bernstein DI · PubMed 25918132

    Diisocyanates, reactive chemicals used to produce polyurethane products, are the most common causes of occupational asthma. The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. Genome-wide single nucleotide polymorphism (SNP) genotyping was performed in 74 diisocyanate-exposed workers with DA and 824 healthy controls using Omni-2.5 and Omni-5 SNP microarrays. We identified 11 SNPs that exceeded genome-wide significance; the strongest association was for the rs12913832 SNP located on chromosome 15, which has been mapped to the HERC2 gene (p = 6.94 × 10(-14)). Strong associations were also found for SNPs near the ODZ3 and CDH17 genes on chromosomes 4 and

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • occupational asthma risk from diisocyanate exposure Moderate

    GWAS evidence indicates genetic predisposition to diisocyanate-induced asthma in G-allele carriers.

    Review occupational exposure history and discuss respiratory function screening needs.

Lifestyle

  • occupational exposure to diisocyanates Moderate

    CLSTN1 G-allele carriers show markedly increased risk of asthma when exposed to diisocyanates in occupational settings.

    Avoid or minimize exposure; use respiratory protection if exposure unavoidable.

Screening

  • baseline respiratory assessment if diisocyanate exposure Moderate

    Early detection of airway dysfunction may prevent progression to chronic occupational asthma in genetically susceptible individuals.

    Obtain baseline spirometry; repeat annually if ongoing exposure.