rs114175587 - RN7SL802P - OR7H2P

Magnitude 4.5 · 1 study on file

Reported associations

• Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci - Unknown journal (n.d.) · Unknown authors · PubMed 32372009

  ABSTRACT: Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N=117 438) and follow-up on promising variants in Stage 2 studies (N=293 787) in five ancestry groups. Through combined meta-

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