rs114145405 - CLNK
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Serum urate level testing Moderate
CLNK rs114145405 associates with elevated serum urate; baseline and periodic monitoring assesses individual risk
Baseline serum urate assessment; repeat annually or per physician recommendation
- GWAS_CATALOG:33462484
Discuss with your doctor
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Urate level management and gout prevention strategy Moderate
CLNK variant associates with elevated serum urate, a modifiable risk factor for gout and metabolic complications
Review baseline urate level, establish monitoring plan, discuss diet, weight, and hydration optimization
- GWAS_CATALOG:33462484