Expressive

rs114119990 - RNA5SP63 - U3

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans - Unknown journal (n.d.) · Unknown authors · PubMed 35165267

    ABSTRACT: Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead S

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean or DASH diet pattern Moderate

    Genetic predisposition to increased carotid intima-media thickness indicates elevated cardiovascular disease risk mitigated by dietary modification.

    Adopt Mediterranean or DASH diet; limit saturated fat intake to less than 7% of daily calories.

Discuss with your doctor

  • cardiovascular risk assessment with physician Moderate

    Genetic variant associated with increased carotid intima-media thickness warrants discussion of personalized cardiovascular disease prevention.

Exercise

  • regular aerobic exercise for cardiovascular health Moderate

    Genetic predisposition to increased carotid intima-media thickness indicates elevated cardiovascular disease risk benefiting from regular physical activity.

    150 minutes of moderate-intensity aerobic exercise per week, or 75 minutes vigorous-intensity per week.

Screening

  • carotid intima-media thickness assessment Moderate

    Genetic variant associated with increased carotid intima-media thickness, a marker of subclinical atherosclerosis and cardiovascular disease risk.

    Baseline carotid artery ultrasound; repeat every 5 years or per physician recommendation.