Expressive

rs114116510 - LINC01756 - LINC01648

Magnitude 4.5 · 1 study on file

Reported associations

  • Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923

    ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting triglyceride level Moderate

    rs114116510 A allele is associated with higher triglyceride levels in large population study

    Fasting triglyceride test at least annually

Diet

  • Omega-3 rich foods Moderate

    Omega-3 polyunsaturated fats reduce triglyceride levels and may counteract genetic elevation

    Fish 2-3 times weekly or daily plant source like flaxseed or chia (1-2 tablespoons)

  • Reduce refined carbohydrates and added sugars Moderate

    Refined carbohydrates raise triglyceride levels; limitation may offset genetic predisposition

    Limit added sugars to less than 25g daily; prefer whole grains over refined

Discuss with your doctor

  • Genetic triglyceride risk and management strategy Moderate

    Genetic predisposition to elevated triglycerides warrants medical assessment and personalized intervention planning

    Discuss with healthcare provider; consider targeted lipid management if indicated

Exercise

  • Aerobic exercise Moderate

    Aerobic activity reduces triglyceride levels and provides benefit for genetic predisposition

    150 minutes moderate-intensity aerobic exercise weekly or equivalent