rs11406702 - CFAP144P2 - IL1RL1
Magnitude 2.2 · 1 study on file
Reported associations
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Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation - Unknown journal (n.d.) · Unknown authors · PubMed 36653354
ABSTRACT: Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the sinonasal tract, pharynx and larynx, are growing health problems yet their genomic similarity is not known. We analyze genome-wide association to eight upper respiratory diseases (61,195 cases) among 260,405 FinnGen participants, meta-analyzing diseases in four groups based on an underlying genetic correlation structure. Aiming to understand which genetic loci contribute to susceptibility to upper respiratory diseases in general and its subtypes, we detect 41 independent genome-wide significant loci, distinguishing impact on sinonasal or pharyngeal diseases, or both. Fine-mapping implicated non-synonymous variants in nine genes, including three linked to immune-related diseases. Phen
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Environmental allergen reduction Moderate
Reduced allergen exposure minimizes allergic rhinitis symptoms in genetically susceptible individuals
Maintain HEPA filtration, control indoor humidity 30-50%, minimize pollen exposure during high-pollen seasons
Screening
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Allergic rhinitis screening Moderate
Genetic association with allergic rhinitis identifies individuals at elevated risk who benefit from screening
Consult healthcare provider for allergy testing, including IgE panel for common allergens