rs114062146 - ST18 - ALKAL1
Magnitude 4.5 · 1 study on file
Reported associations
-
Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility. - American journal of human genetics (2025) · Betti MJ, Jaworski J, Zhao S, Rao JS, Ryan BM, Schwartz AG, Lusk CM, McCoy L, Wiencke JK, Bruce MA, Chanock S, Gamazon ER, Hellwege JN, Aldrich MC · PubMed 40829600
Striking disparities in lung cancer exist, with Black/African American individuals disproportionately affected by lung cancer, yet the genetic architecture in African ancestry individuals is poorly understood. We aimed to address this by performing a comprehensive genetic association study of lung cancer, incorporating local ancestry, across 6,490 African ancestry individuals (2,390 individuals with lung cancer and 4,100 control subjects). We identified a single genome-wide significant (p < 5 × 10 ) locus, 15q25.1 (lead SNP rs17486278, OR [95% CI] = 1.34 [1.23-1.45], p = 4.52 × 10 ), that has consistently shown a strong association with lung cancer across populations. Additionally, we identified nine suggestive (p < 1 × 10 ) loci. Four of these loci (3p12.1, 8q22.2, 14q11.2, and 18q22.3
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic lung cancer risk and personalized screening plan Moderate
GWAS evidence of 1.73-fold increased lung cancer risk in smokers warrants professional assessment of surveillance strategy and prevention measures
Discuss this genetic finding with your doctor to develop a personalized screening and risk-management plan
Lifestyle
-
smoking Moderate
This variant increases lung cancer risk 1.73-fold in smokers, indicating heightened susceptibility to tobacco carcinogens
Complete cessation if currently smoking; seek counseling or pharmacotherapy if needed