rs11403745 - GOT1-DT - LINC01475
Magnitude 2.2 · 1 study on file
Reported associations
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GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression - Unknown journal (n.d.) · Unknown authors · PubMed 33608531
ABSTRACT: Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6, FUT2, PSCA, ABO, CDX2, GAST and CCKBR. There are previously established roles in susceptibility to Helicobacter pylori infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight t
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for inflammatory bowel disease Moderate
rs11403745 C-allele increases IBD odds ratio by 1.12; associated with altered intestinal expression of LINC01475
Discuss results with gastroenterologist or primary care provider for risk stratification and screening discussion