rs114019803 - IL12B-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy - Unknown journal (n.d.) · Unknown authors · PubMed 35997131

  ABSTRACT: Background: Multiple System Atrophy is a rare neurodegenerative disease with alpha-synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautonomia, parkinsonism, and cerebellar ataxia. One prior genome-wide association study in mainly clinically diagnosed patients with Multiple System Atrophy failed to identify genetic variants predisposing for the disease. Objective: Since the clinical diagnosis of Multiple System Atrophy yields a high rate of misdiagnosis when compared to the neuropathological gold standard, we studied only autopsy-confirmed cases. Methods: We studied common genetic variations in Multiple System Atrophy cases (N = 731) and controls (N = 2898). Results: The most stro

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