rs11399393 - LINC02712
Magnitude 2.8 · 1 study on file
Reported associations
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Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial - Unknown journal (n.d.) · Unknown authors · PubMed 35543701
ABSTRACT: Background: Statin-associated muscle symptoms (SAMS) are the most frequently reported adverse events for statin therapies. Previous studies have reported an association between the p.Val174Ala missense variant in SLCO1B1 and SAMS in simvastatin-treated subjects; however, evidence for genetic predictors of SAMS in atorvastatin- or rosuvastatin-treated subjects is currently lacking. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; n=18 924) was a double-blind, randomized, placebo-controlled study evaluating the efficacy and safety of alirocumab (a PCSK9 [proprotein convertase subtilisin/kexin type 9] inhibitor) in acute coronary syndrome patients receiving high-intensity statin therapy. The goal of
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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statin intolerance risk and lipid management alternatives Moderate
Genetic association with statin intolerance warrants discussion of risk-benefit and alternative therapies
Screening
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muscle symptoms if on statin therapy Moderate
LINC02712 rs11399393 associates with statin intolerance and muscle symptoms, suggesting elevated risk during statin use
report muscle pain, weakness, or cramps to physician; consider statin holiday to test symptoms