rs113986290 - LNC-LBCS

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease - Unknown journal (n.d.) · Unknown authors · PubMed 28067908

  ABSTRACT: Genetic association studies have identified 215 risk loci for inflammatory bowel disease, which have revealed fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals, and meta-analyzed with published summary statistics, yielding a total sample size of 59,957 subjects. We identified 25 new loci, three of which contain integrin genes that encode proteins in pathways identified as important therapeutic targets in inflammatory bowel disease. The associated variants are correlated with expression changes in response to immune stimulus at two of these genes (ITGA4, ITGB8) and at previously implicated loci (ITGAL, ICAM1). In all four cases, the expression increasing allele also increases disease risk. We also identified likely cau

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