rs113920486 - LNCAROD

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study - Unknown journal (n.d.) · Unknown authors · PubMed 35451555

  ABSTRACT: Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects (CHDs). OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities, and epigenetic phenomena. A genome-wide association study was conducted in National Birth Defects Prevention Study participants (Ndiscovery=3,978; Nreplication=2,507), investigating the genetic architecture of OHDs using transmission/disequilibrium tests (TDT) in complete case-parental trios (Ndiscovery_TDT=440; Nreplication_TDT=275) and case-control analyses separately in infants (Ndiscovery_CCI=1,635; Nreplication_CCI=990) and mothers (case status defined by infant; Ndiscovery_CCM=1,703; Nreplication_CCM=1,078). In the TD

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