rs113871023 - LRFN2 - UNC5CL

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians - Unknown journal (n.d.) · Unknown authors · PubMed 32131869

  ABSTRACT: Background Hallux valgus, one of the most common structural foot deformities, is highly heritable. However, previous efforts to elucidate the genetic underpinnings of hallux valgus through a genome-wide association study (GWAS) conducted in 4409 Caucasians did not identify genome-wide significant associations with hallux valgus in both gender-specific and sex-combined GWAS meta-analyses. In this analysis, we add newly available data and more densely imputed genotypes to identify novel genetic variants associated with hallux valgus. Methods A total of 5925 individuals of European Ancestry were categorized into two groups: 'hallux valgus present' (n = 2314) or 'no deformity' (n = 3611) as determined by trained examiners or using the Manchester grading scale. Genotyp

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