rs113866309 - LLPH
Magnitude 4.5 · 1 study on file
Reported associations
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Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations - Unknown journal (n.d.) · Unknown authors · PubMed 28498854
ABSTRACT: Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and hypertension in people of African ancestry, we performed both single and multiple-trait genome-wide association analyses. We analyzed 21 genome-wide association studies comprised of 31,968 individuals of African ancestry, and validated our results with additional 54,395 individuals from multi-ethnic studies. These analyses identified nine loci with eleven independent variants which reached genome-wide significance (P < 1.25×10−8) for either systolic and diastolic blood pressure, hyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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blood pressure and pulse pressure screening High
rs113866309-C allele is associated with elevated pulse pressure through effects on TMBIM4-mediated calcium signaling in vascular smooth muscle, altering response to angiotensin II.
measure blood pressure at least annually; discuss pulse pressure assessment with healthcare provider