Expressive

rs113864631 - OR10J1 - LINC02819

Magnitude 2.2 · 1 study on file

Reported associations

  • A genome-wide association study of high-sensitivity C-reactive protein in a large Korean population highlights its genetic relationship with cholesterol metabolism - Unknown journal (n.d.) · Unknown authors · PubMed 39747571

    ABSTRACT: High-sensitivity C-reactive protein (hsCRP) is a representative biomarker of systemic inflammation and is associated with numerous chronic diseases. To explore the biological pathways and functions underlying chronic inflammation, we conducted a genome-wide association study (GWAS) and several post-GWAS analyses of the hsCRP levels. This study was performed on data from 71,019 Koreans and is one of the largest East Asian studies. Overall, 69 independent single nucleotide polymorphisms (SNPs) were identified, including 13 novel variants. The implicated genes and pathways are primarily involved in cholesterol metabolism and the immune response. A phenome-wide association study was performed based on a polygenic risk score (PRS) constructed using 69 hsCRP-associated SNPs. Notably, t

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • anti-inflammatory diet patterns Moderate

    Mediterranean-style and other anti-inflammatory diets reduce systemic CRP levels and may mitigate the elevated inflammation associated with this variant

    Consider Mediterranean diet or similar anti-inflammatory eating patterns

Exercise

  • regular aerobic exercise Moderate

    Aerobic activity is one of the most effective lifestyle interventions for reducing CRP levels

    Aim for 150 minutes of moderate-intensity aerobic exercise per week

Lifestyle

  • stress reduction and sleep optimization Moderate

    Chronic stress and poor sleep elevate CRP levels; improving both may help offset the increased inflammation associated with this variant

    Practice stress reduction techniques (meditation, yoga); aim for 7-9 hours of quality sleep nightly

Screening

  • high-sensitivity C-reactive protein levels Moderate

    rs113864631 C allele is significantly associated with elevated CRP, a marker of systemic inflammation and cardiovascular risk

    Obtain baseline measurement; monitor annually or per clinical guidance