rs113861932 - MYH15
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types - Unknown journal (n.d.) · Unknown authors · PubMed 37862240
ABSTRACT: Abstract Background This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). Methods A genome-wide association study meta-analysis was performed using 19 cohorts totaling 12 042 patients. Acute standardized total average toxicity (STATacute) was modelled using a generalized linear regression model for additive effect of genetic variants, adjusted for demographic and clinical covariates (rSTATacute). Linkage disequilibrium score regression estimated shared single-nucleotide variation (SNV-formerly SNP)-based heritability of rSTATacute in all patients and for each cancer type. Results Shared SNV-based heritability of STATacut
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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acute radiation toxicity risk during cancer treatment Moderate
MYH15 variant G allele associates with increased acute radiotoxicity during cancer radiation therapy, possibly affecting DNA repair or tissue damage response.
If planning cancer radiation therapy, discuss this variant with your oncology team before treatment.