Expressive

rs11385942 - LZTFL1

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genomewide Association Study of Severe Covid-19 with Respiratory Failure - Unknown journal (n.d.) · Unknown authors · PubMed 32558485

    ABSTRACT: Abstract Background There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. Methods We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the

  • Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19 - Unknown journal (n.d.) · Unknown authors · PubMed 33949668

    ABSTRACT: Abstract The systematic identification of host genetic risk factors is essential for the understanding and treatment of coronavirus disease 2019 (COVID-19). By performing a meta-analysis of two independent genome-wide association summary datasets (N = 680 128), a novel locus at 21q22.11 was identified to be associated with COVID-19 infection (rs9976829 in IFNAR2-IL10RB, odds ratio = 1.16, 95% confidence interval = 1.09-1.23, P = 2.57 × 10−6). The rs9976829 represents a strong splicing quantitative trait locus for both IFNAR2 and IL10RB genes, especially in lung tissue (P = 1.8 × 10−24). Integrative genomics analysis of combining genome-wide association study with expression quantitative trait locus data showed the expression variations of IFN

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic risk for COVID-19 severity High

    LZTFL1 variant affects immune signaling pathways; increases COVID-19 susceptibility and severe respiratory disease risk

    Discuss genetic risk and personalized prevention strategy at next appointment

Screening

  • COVID-19 vaccination High

    rs11385942 variant increases COVID-19 infection risk and severe respiratory disease (OR 1.6-2.1); vaccination provides robust prevention

    Ensure current vaccination status; discuss booster strategy with healthcare provider

  • Early COVID-19 testing if exposed Moderate

    Higher genetic risk for infection and rapid progression to severe disease; early detection enables timely clinical intervention

    Consider rapid antigen or PCR testing within 24 hours of exposure; monitor for symptoms