rs113788164 - HLA-DRB9 - HLA-DRB5

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 29458411

  ABSTRACT: Background Simultaneous consideration of two neuropathological traits related to Alzheimer's disease (AD) has not been attempted in a genome-wide association study. Methods We conducted genome-wide pleiotropy analyses using association summary statistics from the Beecham et al. study (PLoS Genet 10:e1004606, 2014) for AD-related neuropathological traits, including neuritic plaque (NP), neurofibrillary tangle (NFT), and cerebral amyloid angiopathy (CAA). Significant findings were further examined by expression quantitative trait locus and differentially expressed gene analyses in AD vs. control brains using gene expression data. Results Genome-wide significant pleiotropic associations were observed for the joint model of NP and NFT (NP + NFT) with the single-nucleotide polymorph

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