rs113785116 - Y_RNA - CARS1P2
Magnitude 2.2 · 1 study on file
Reported associations
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Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders - Unknown journal (n.d.) · Unknown authors · PubMed 34099189
ABSTRACT: BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. METHODS: We conducted the largest to date genome-wide genotype-by-sex (GxS) interaction of risk for these disorders, using 85,735 cases (33,403 SCZ, 19,924 BIP, 32,408 MDD) and 109,946 controls from the Psychiatric Genomics Consortium (PGC) and iPSYCH. RESULTS: Across disorders, genome-wide significant SNP-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815; p=3.2×10−8), that interacts with sodium/potassium-transporting ATPase enzymes impli
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic psychiatric risk and family history High
Carriers of the risk allele have increased genetic liability for schizophrenia, bipolar disorder, and major depressive disorder per large GWAS studies
Review family history of mental illness, personal symptom history, and establish preventive care plan
Screening
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mental health assessment and monitoring High
rs113785116 associates with increased genetic predisposition to schizophrenia, bipolar disorder, and major depressive disorder
Discuss baseline psychiatric screening with healthcare provider; consider regular monitoring using validated assessment tools