rs113776891 - PTPRM

Magnitude 4.5 · 1 study on file

Reported associations

• First genome-wide association study of non-severe malaria in two birth cohorts in Benin. - Human genetics (2019) · Milet J, Boland A, Luisi P, Sabbagh A, Sadissou I, Sonon P, Domingo N, Palstra F, Gineau L, Courtin D, Massougbodji A, Garcia A, Deleuze JF, Perdry H · PubMed 31667592

  Recent research efforts to identify genes involved in malaria susceptibility using genome-wide approaches have focused on severe malaria. Here, we present the first GWAS on non-severe malaria designed to identify genetic variants involved in innate immunity or innate resistance mechanisms. Our study was performed on two cohorts of infants from southern Benin (525 and 250 individuals used as discovery and replication cohorts, respectively) closely followed from birth to 18-24 months of age, with an assessment of a space- and time-dependent environmental risk of exposure. Both the recurrence of mild malaria attacks and the recurrence of malaria infections as a whole (symptomatic and asymptomatic) were considered. Post-GWAS functional analyses were performed using positional, eQTL, and chrom

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.