Expressive

rs113759232 - LINC02499

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci - Unknown journal (n.d.) · Unknown authors · PubMed 35347128

    ABSTRACT: Few studies have explored the impact of rare variants (minor allele frequency < 1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish population provides an ideal opportunity for such explorations, given the multiple bottlenecks and expansions that have shaped its history, and the enrichment for many otherwise rare alleles that has resulted. Here, we report genetic associations for 1391 plasma metabolites in 6136 men from the late-settlement region of Finland. We identify 303 novel association signals, more than one third at variants rare or enriched in Finns. Many of these signals identify genes not previously implicated in metabolite genome-wide association studies and suggest mechanisms for diseases and disease-related traits. The Finnis

  • Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study - Unknown journal (n.d.) · Unknown authors · PubMed 29084231

    ABSTRACT: Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005<minor allele frequency [MAF]<0.05) or rare (MAF<0.005) variant, including Arg123His in LCAT. Gene-based associations (P<10−10) support a role for coding variants in LIPC and LIPG w

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • LDL particle size and concentration High

    This variant increases small LDL particle concentration, a risk factor for cardiovascular disease

    Baseline lipid panel with particle analysis; annual follow-up

Diet

  • refined grains and added sugars Moderate

    Refined carbohydrates increase small LDL production; this variant increases baseline small LDL

    Limit refined carbs to under 25 percent of daily caloric intake

Exercise

  • aerobic exercise for lipid profile Moderate

    Regular aerobic activity reduces small LDL particle concentration, which this variant increases

    150 minutes of moderate-intensity aerobic exercise per week

Screening

  • Cardiovascular risk assessment High

    Elevated small LDL concentration increases atherosclerosis and coronary disease risk

    Initial assessment by age 30-40; sooner if other risk factors present