rs113758558 - LINC02562 - LINC02483
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 40708016
ABSTRACT: Background Alzheimer's disease (AD) risk variants have been identified in European ancestry cohorts that have stronger effects at certain ages, in individuals with a specific sex, or in those with specific isoforms of APOE, the strongest AD risk locus. However, sample sizes in African ancestry (AA) cohorts have been underpowered to perform stratified analyses. Methods We generated genome-wide association study datasets stratified by sex, age at onset (< 75 vs ≥ 75), and APOE-ε4 carrier status in AA cohorts from MVP and the Alzheimer's Disease Genetics Consortium (ADGC). Outcomes in MVP were AD and related dementias (ADRD; n = 4073 cases and 19,648 controls) and proxy dementia (i.e., reported dementia in a parent, n = 6216 cases and 21,566 controls) while ADGC
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for early-onset Alzheimer's disease Moderate
Carriers of rs113758558 A allele show approximately 77% higher odds of Alzheimer's disease with onset before age 75
Screening
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Baseline cognitive assessment at age 50-55 Moderate
Early-onset Alzheimer's disease may begin cognitive changes in 5th-6th decade in genetic risk carriers; baseline testing enables earlier detection of decline
Neuropsychological evaluation at age 50-55, then periodic follow-up