rs113746805 - SCAF4
Magnitude 2.2 · 1 study on file
Reported associations
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Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304
ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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dietary fiber and plant sterols Moderate
Dietary fiber and plant sterols lower LDL cholesterol, helping mitigate genetic predisposition to elevated lipid levels
Target 25-30g fiber daily; consider plant sterol products or fortified foods providing 2g daily
Exercise
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cardiovascular exercise for lipid management Moderate
Regular aerobic exercise reduces LDL and increases HDL, counteracting genetic predisposition to elevated LDL levels
150 minutes moderate intensity or 75 minutes vigorous intensity aerobic exercise per week
Screening
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lipid panel screening Moderate
Genetic predisposition to elevated LDL requires periodic monitoring to enable timely intervention
Lipid panel every 4-5 years or annually if other cardiovascular risk factors present