rs113741905 - RCC2 - ARHGEF10L

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic predisposition may not improve prediction of cardiac surgery-associated acute kidney injury - Unknown journal (n.d.) · Unknown authors · PubMed 37124606

  ABSTRACT: Background: The recent integration of genomic data with electronic health records has enabled large scale genomic studies on a variety of perioperative complications, yet genome-wide association studies on acute kidney injury have been limited in size or confounded by composite outcomes. Genome-wide association studies can be leveraged to create a polygenic risk score which can then be integrated with traditional clinical risk factors to better predict postoperative complications, like acute kidney injury. Methods: Using integrated genetic data from two academic biorepositories, we conduct a genome-wide association study on cardiac surgery-associated acute kidney injury. Next, we develop a polygenic risk score and test the predictive utility within regressions controlling for age

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