rs113730106 - SYT16

Magnitude 2.0 · 1 study on file

Reported associations

• The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population. - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2020) · Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ · PubMed 30920136

  ABSTRACT: Genetic variation across the HLA is known to influence renal-transplant outcome. However, the impact of genetic variation beyond the HLA is less clear. We tested the association of common genetic variation and clinical characteristics, from both the donor and recipient, with post-transplant eGFR at different time-points, out to 5-years post-transplantation. We conducted GWAS meta-analyses across 10,844 donors and recipients from five European ancestry cohorts. We also analysed the impact of polygenic risk scores (PRS), calculated using genetic variants associated with non-transplant eGFR, on post-transplant eGFR. PRS calculated using the recipient genotype alone, as well as combined donor and recipient genotypes were significantly associated with eGFR at 1-year post-transplant. 3

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