Expressive

rs11371318 - ODAD2

Magnitude 2.2 · 1 study on file

Reported associations

  • Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals - Unknown journal (n.d.) · Unknown authors · PubMed 34852643

    ABSTRACT: Objective: Carotid artery intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. Twenty susceptibility loci for cIMT were previously identified and the identification of additional susceptibility loci furthers our knowledge on the genetic architecture underlying atherosclerosis. Approach and Results: We performed 3 genome-wide association studies in 45 185 participants from the UK Biobank study who underwent cIMT measurements and had data on minimum, mean, and maximum thickness. We replicated 15 known loci and identified 20 novel loci associated with cIMT at P<5×10−8. Seven novel loci (ZNF385D, ADAMTS9, EDNRA, HAND2, MYOCD, ITCH/EDEM2/MMP24, and MRTFA) were identified in all 3 phenotypes. An additional new locus (LOXL1) was identified in th

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean or DASH diet pattern Moderate

    Genetic atherosclerosis risk supports anti-inflammatory dietary intervention

    Emphasize vegetables, whole grains, fish, olive oil; limit saturated fat and processed foods

Discuss with your doctor

  • Cardiovascular risk assessment and prevention strategy Moderate

    Genetic variant associated with increased carotid intima media thickness, reflecting elevated atherosclerosis risk

Lifestyle

  • Regular aerobic exercise Moderate

    Genetic atherosclerosis risk supports cardiovascular protection through physical activity

    150 minutes moderate-intensity or 75 minutes vigorous aerobic exercise weekly

Screening

  • Carotid ultrasound imaging Moderate

    GWAS variant associated with increased carotid intima media thickness, a subclinical atherosclerosis marker

    Discuss screening with healthcare provider; consider baseline assessment at age 40-45