rs1137 - SEMA4F - RPS28P5

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic Variants on Chromosome 1q41 Influence Ocular Axial Length and High Myopia - Unknown journal (n.d.) · Unknown authors · PubMed 22685421

  ABSTRACT: As one of the leading causes of visual impairment and blindness, myopia poses a significant public health burden in Asia. The primary determinant of myopia is an elongated ocular axial length (AL). Here we report a meta-analysis of three genome-wide association studies on AL conducted in 1,860 Chinese adults, 929 Chinese children, and 2,155 Malay adults. We identified a genetic locus on chromosome 1q41 harboring the zinc-finger 11B pseudogene ZC3H11B showing genome-wide significant association with AL variation (rs4373767, β = −0.16 mm per minor allele, Pmeta = 2.69×10−10). The minor C allele of rs4373767 was also observed to significantly associate with decreased susceptibility to high myopia (per-allele odds ratio (OR) = 0.75, 95% CI: 0.68-0.84, Pmeta = 

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