rs113637199 - OSBPL5
Magnitude 4.5 · 1 study on file
Reported associations
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Risk of Revision After Arthroplasty Associated with Specific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 Twins Treated with Arthroplasty. - The Journal of bone and joint surgery. American volume (2025) · Brüggemann A, Eriksson N, Michaëlsson K, Hailer NP · PubMed 34982741
The risk of revision surgery following total joint arthroplasty (TJA) may be influenced by genetic factors. Therefore, we sought to identify genetic variants associated with the risk of revision surgery in a genomewide association study. We investigated a cohort of 1,130 twins from the Swedish Twin Registry treated with TJA. During a mean of 9.4 years of follow-up, 75 individuals underwent revision surgery for aseptic loosening (the primary outcome) and 94, for any reason (the secondary outcome). Genetic information was collected using the Illumina OmniExpress and PsychArray panels, and the Haplotype Reference Consortium served as the reference for gene imputation. Adjusted Cox regression models were fitted to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). Nine single-n
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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OSBPL5 variant review before hip arthroplasty Moderate
Carriers of the C allele at rs113637199 show 3.6-fold increased risk of aseptic loosening requiring revision surgery after hip replacement.
Inform orthopedic surgeon of genotype status if hip arthroplasty is planned.