Expressive

rs113629060 - STAG1

Magnitude 2.2 · 1 study on file

Reported associations

  • Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation - Unknown journal (n.d.) · Unknown authors · PubMed 35213538

    ABSTRACT: Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on the basis that they primarily modify low-density lipoprotein (LDL) cholesterol (HMGCR, PCKS9, and NPC1L1), high-density lipoprotein (HDL) cholesterol (CETP), or triglycerides (APOC3, ANGPTL3, ANGPTL4, and LPL). Conducting mendelian randomisation (MR) provided strong evidence of an effect of drug-based genetic scores on coronary artery disease (CAD) risk with the exception of ANGPTL3. We then systematically estimated the effects of each score on 249 metabolic traits derived using blood samples from an unprecedented sample size of up to

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Lipid panel with triglyceride and HDL levels Moderate

    rs113629060 is associated with elevated triglycerides and altered HDL composition; baseline measurement establishes individual phenotype.

    Baseline lipid panel, then every 1-2 years or annually if elevated

Diet

  • Reduce refined carbohydrates and added sugars Moderate

    Refined carbohydrates increase triglyceride synthesis; rs113629060 carriers have genetic predisposition to elevated triglycerides.

    Limit refined grains, sugary beverages to <10% daily calories; target <25g added sugar daily

Discuss with your doctor

  • Personalized lipid management strategy Moderate

    rs113629060 genetic predisposition to elevated triglycerides warrants personalized cardiovascular risk assessment and management.

Exercise

  • Regular aerobic exercise Moderate

    Aerobic exercise reduces triglyceride levels and improves HDL composition; particularly beneficial for genetic predisposition.

    150 minutes moderate-intensity aerobic activity per week