Expressive

rs113626770 - LINC02523, HEY2-AS1

Magnitude 4.5 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • daily broad-spectrum sunscreen SPF 30+ High

    rs113626770 G allele confers increased risk of solar radiation dermatitis in large cohort (n=610503)

    apply to exposed skin daily; reapply every 2 hours after water exposure

  • minimize sun exposure 10am-4pm High

    rs113626770 G allele associates with 2.24-fold increased dermatitis from solar radiation

    limit outdoor activities during peak UV hours

  • wear protective clothing outdoors High

    physical barriers provide effective UV protection for genetically high-risk individuals

    long sleeves, brimmed hat, UV-blocking sunglasses when outdoors

Screening

  • annual dermatologic examination High

    baseline and periodic monitoring appropriate for individuals with high genetic risk of solar radiation dermatitis

    schedule annual full-body skin examination with dermatologist