rs113607577 - TRPM6
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study - Unknown journal (n.d.) · Unknown authors · PubMed 26058915
ABSTRACT: Background Low serum magnesium levels have been associated with multiple chronic diseases. The regulation of serum magnesium homeostasis is not well understood. A previous genome-wide association study (GWAS) of European ancestry (EA) populations identified nine loci for serum magnesium. No such study has been conducted in African-Americans, nor has there been an evaluation of the interaction of magnesium-associated SNPs with environmental factors. The goals of this study were to identify genetic loci associated with serum magnesium in an African-American (AA) population using both genome-wide and candidate region interrogation approaches and to evaluate gene-environment interaction for the magnesium-associated variants in both EA and AA populations. We conducted a GWAS of serum
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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adequate dietary magnesium intake Moderate
TRPM6 G allele rs113607577 is associated with lower serum magnesium levels, linked to cardiovascular and metabolic disease risk.
Ensure magnesium intake from food sources (leafy greens, nuts, seeds, legumes, whole grains); target RDA of 310-420 mg/day based on age/sex.