Expressive

rs113591949 - LCORL

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to insomnia management Moderate

    LCORL variant rs113591949 shows strong association with insomnia; clinical guidance optimizes individual management strategies

    Share results with physician; discuss family history of sleep disorders and symptom management options

Lifestyle

  • Sleep quality and insomnia symptoms Moderate

    rs113591949 risk allele A associates with significantly elevated insomnia risk; active monitoring enables early detection

    Track sleep onset latency, total sleep duration, and daytime function weekly

Screening

  • Sleep disorder evaluation or sleep study Moderate

    Genetic association with insomnia warrants clinical assessment to identify and manage sleep disorders

    Discuss with physician; consider formal sleep study if symptoms warrant