Expressive

rs113529636 - TAF4

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic analysis of elevated levels of creatinine and cystatin C biomarkers reveals novel genetic loci associated with kidney function - Unknown journal (n.d.) · Unknown authors · PubMed 39927731

    ABSTRACT: Abstract The rising prevalence of chronic kidney disease (CKD), affecting an estimated 37 million adults in the United States, presents a significant global health challenge. CKD is typically assessed using estimated Glomerular Filtration Rate (eGFR), which incorporates serum levels of biomarkers such as creatinine and cystatin C. However, these biomarkers do not directly measure kidney function; their elevation in CKD results from diminished glomerular filtration. Genome-wide association studies (GWAS) based on eGFR formulas using creatinine (eGFRcre) or cystatin C (eGFRcys) have identified distinct non-overlapping loci, raising questions about whether these loci govern kidney function or biomarker metabolism. In this study, we show that GWAS on creatinine and cystatin C levels

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • moderate dietary sodium intake Moderate

    high sodium elevates blood pressure and stresses glomerular filtration; relevant given genetic predisposition to reduced eGFR

    aim for less than 2300 mg sodium daily

Discuss with your doctor

  • kidney function assessment and monitoring plan Moderate

    GWAS finding of reduced eGFR risk warrants clinical evaluation and personalized screening strategy

    discuss with primary care physician or nephrologist if not yet evaluated

Lifestyle

  • maintain consistent hydration Moderate

    adequate hydration supports glomerular filtration rate and kidney function

    target pale yellow urine; drink water consistently throughout the day

Screening

  • kidney function panel Moderate

    rs113529636 in TAF4 is associated with reduced eGFR; regular monitoring detects changes early

    eGFR, serum creatinine, cystatin C annually per provider