Expressive

rs113501294 - SF3B3

Magnitude 2.2 · 1 study on file

Reported associations

  • Large-scale cross-ancestry genome-wide meta-analysis of serum urate - Unknown journal (n.d.) · Unknown authors · PubMed 38658550

    ABSTRACT: Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of serum urate requires exploration. A large-scale cross-ancestry genome-wide association meta-analysis of 1,029,323 individuals and ancestry-specific meta-analysis identifies a total of 351 loci, including 17 previously unreported loci. The genetic architecture of serum urate control is similar between European and East Asian populations. A transcriptome-wide association study, enrichment analysis, and colocalization analysis in relevant tissues identify candidate serum urate-associated genes, including CTBP1, SKIV2L, and WWP2. A phenome-wide ass

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • alcohol, especially beer Moderate

    Alcohol increases urate production and decreases renal excretion; beer has additional purines

    Limit to 1-2 drinks per week; prefer wine or spirits over beer

  • limiting purine-rich foods Moderate

    Dietary purines are metabolized to urate; SNP carriers have genetic predisposition to elevated urate

    Limit organ meats, anchovies, sardines, red meat; emphasize lean protein and plant sources

Lifestyle

  • increased hydration Moderate

    Higher urine volume increases urate solubility and urinary excretion

    Drink 2-3 liters of water daily, more when exercising or in warm climates

Screening

  • serum urate level Moderate

    This SNP is strongly associated with increased serum urate (GWAS p=3e-11), a precursor to gout

    Annual serum urate measurement, more frequent if family history of gout