Expressive

rs113471597 - RPL31P34 - GRID2IP

Magnitude 2.2 · 1 study on file

Reported associations

  • Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank. - Nature genetics (2022) · McDonald MN, Lakshman Kumar P, Srinivasasainagendra V, Nair A, Rocco AP, Wilson AC, Chiles JW, Richman JS, Pinson SA, Dennis RA, Jagadale V, Brown CJ, Pyarajan S, Tiwari HK, Bamman MM, Singh JA · PubMed 36411363

    Osteoarthritis is a common progressive joint disease. As no effective medical interventions are available, osteoarthritis often progresses to the end stage, in which only surgical options such as total joint replacement are available. A more thorough understanding of genetic influences of osteoarthritis is essential to develop targeted personalized approaches to treatment, ideally long before the end stage is reached. To date, there have been no large multiancestry genetic studies of osteoarthritis. Here, we leveraged the unique resources of 484,374 participants in the Million Veteran Program and UK Biobank to address this gap. Analyses included participants of European, African, Asian and Hispanic descent. We discovered osteoarthritis-associated genetic variation at 10 loci and replicated

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • low-impact aerobic and resistance exercise Moderate

    Strengthens muscles supporting joints, reduces cartilage stress, slows osteoarthritis progression

    3-4 times weekly, 30 minutes moderate intensity (e.g., swimming, cycling, walking, strength training)

Lifestyle

  • joint pain, swelling, and stiffness progression Moderate

    Early detection of osteoarthritis allows earlier intervention to slow progression and maintain function

    Track joint symptoms regularly; report persistent pain or limited range of motion to healthcare provider

Screening

  • osteoarthritis screening or baseline imaging Moderate

    Genetic variant rs113471597 associated with increased osteoarthritis risk (GWAS p=4.00e-10, n>2M subjects)

    Consider baseline joint assessment or imaging by age 40, or when symptoms first appear