rs113430717 - COPG1
Magnitude 2.2 · 1 study on file
Reported associations
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Interaction between cigarette smoking and genetic polymorphisms on the associations with age of natural menopause and reproductive lifespan: the Singapore Chinese Health Study. - Human reproduction (Oxford, England) (2022) · Huang Z, Chang X, Wang L, Liu J, Heng CK, Khor CC, Yuan JM, Koh WP, Dorajoo R · PubMed 35413122
Are there genetic variants that interact with smoking to reduce reproductive lifespan in East-Asian women? Our study corroborates several recently identified genetic loci associated with reproductive lifespan and highlights specific genetic predispositions that may interact with smoking status to adversely affect reproductive lifespan in East-Asian women. Epidemiological data as well as evaluations on genetic predisposition to smoke indicate on the importance of smoking in adverse effects on reproductive lifespan in women. However, there are no previous smoking and gene interaction studies for reproductive traits in East-Asian women. This population-based prospective cohort study comprised 11 643 East-Asian Chinese women with overlapping genome-wide genotyping and reproductive data. We pe
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Menopause timing and reproductive health planning Moderate
This variant predisposes to altered age at menopause (effect 0.629 years), which may affect family planning and reproductive health decisions.
Lifestyle
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Smoking Moderate
Smoking adversely affects reproductive lifespan and menopause timing in genetically predisposed women.