Expressive

rs113389818 - RPL23AP56 - LINC01591

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM polygenic risk score study. - Environmental research (2025) · Kelchtermans J, March ME, Mentch F, Qu H, Liu Y, Nguyen K, Hakonarson H · PubMed 39725137

    Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap. To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma. We complete a GWAS in pediatric patients with asthma frequently exposed to AAP, comparing patients with exacerbations following spikes in AAP to patients without this temporal association and calculate a polygenic risk score (PRS) for PM . This PRS was validated using internal data and data from the All of Us cohort. We included 6023 patients in the GWAS, restricted to the African ancestry cohort due to the association between AAP exposure and race. Three loci reached genome-wide signifi

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic predisposition to pollutant-induced asthma exacerbations Moderate

    GWAS evidence links this variant to increased asthma exacerbation risk from NO2 air pollution exposure.

    Share genetic findings with healthcare provider to inform environmental exposure assessment and asthma management strategy.

Lifestyle

  • high NO2 air pollution exposure Moderate

    Genetic variant increases susceptibility to asthma exacerbations triggered by NO2 pollution in ambient air.

    Monitor air quality index; limit outdoor activities when NO2 levels exceed EPA standards.

Screening

  • asthma screening or spirometry Moderate

    Genetic variant is associated with increased risk of NO2-triggered asthma exacerbations, particularly in childhood.

    Discuss with healthcare provider, especially if age <18 or living in high-pollution area.