rs113384484 - FAT2 - SPARC
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children - Unknown journal (n.d.) · Unknown authors · PubMed 38136945
ABSTRACT: Mercury has high industrial utility and is present in many products, and environmental contamination and occupational exposure are widespread. There are numerous biological systems involved in the absorption, metabolism, and excretion of Hg, and it is possible that some systems may be impacted by genetic variation. If so, genotype may affect tissue concentrations of Hg and subsequent toxic effects. Genome-wide association testing was performed on blood Hg samples from pregnant women of the Avon Longitudinal Study of Parents and Children (n = 2893) and children of the Human Early Life Exposome (n = 1042). Directly-genotyped single-nucleotide polymorphisms (SNPs) were imputed to the Haplotype Reference Consortium r1.1 panel of whole genotypes and modelled againstlog-transformed Hg.
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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high-mercury fish consumption Low
rs113384484 A allele is associated with higher blood mercury levels, suggesting genetic predisposition to accumulation. Reducing dietary mercury intake helps mitigate this genetic risk.
limit to 1-2 servings per month; prefer low-mercury fish like salmon or sardines