rs11335470 - LINC00944

Magnitude 2.0 · 1 study on file

Reported associations

• Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania - PLoS genetics (2018) · Ravenhall M, Campino S, Sepúlveda N, Manjurano A, Nadjm B, Mtove G, Wangai H, Maxwell C, Olomi R, Reyburn H, Drakeley CJ, Riley EM, Clark TG · PubMed 29381699

  ABSTRACT: Significant selection pressure has been exerted on the genomes of human populations exposed to Plasmodium falciparum infection, resulting in the acquisition of mechanisms of resistance against severe malarial disease. Many host genetic factors, including sickle cell trait, have been associated with reduced risk of developing severe malaria, but do not account for all of the observed phenotypic variation. Identification of novel inherited risk factors relies upon high-resolution genome-wide association studies (GWAS). We present findings of a GWAS of severe malaria performed in a Tanzanian population (n = 914, 15.2 million SNPs). Beyond the expected association with the sickle cell HbS variant, we identify protective associations within two interleukin receptors (IL-23R and IL-12R

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