rs113330417 - GPHN
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores - Unknown journal (n.d.) · Unknown authors · PubMed 31164008
ABSTRACT: Objective: Over 90% of suicide attempters have a psychiatric diagnosis, however twin and family studies suggest that the genetic etiology of suicide attempt (SA) is partially distinct from that of the psychiatric disorders themselves. Here, we present the largest genome-wide association study (GWAS) on suicide attempt using major depressive disorder (MDD), bipolar disorder (BIP) and schizophrenia (SCZ) cohorts from the Psychiatric Genomics Consortium. Method: Samples comprise 1622 suicide attempters and 8786 non-attempters with MDD, 3264 attempters and 5500 non-attempters with BIP and 1683 attempters and 2946 non-attempters with SCZ. SA GWAS were performed by comparing attempters to non-attempters in each disorder followed by meta-analyses across disorders. Polygenic risk scoring
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for suicide attempts in depression Moderate
rs113330417 G allele increases suicide attempt risk 1.75-fold in major depressive disorder, potentially through altered GABAergic inhibitory signaling via gephyrin.
Discuss with psychiatrist or mental health provider if major depressive disorder is diagnosed or suspected