Expressive

rs11332772 - ST6GAL1

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of type 2 diabetes loci in 433,540 East Asian individuals - Unknown journal (n.d.) · Unknown authors · PubMed 32499647

    ABSTRACT: SUMMARY Meta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian individuals, we meta-analyzed GWAS data in 77,418 cases and 356,122 controls. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci newly implicated in T2D predisposition. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. New associations include signals in/near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • refined carbohydrates and added sugars Moderate

    Refined carbs cause rapid glucose spikes; ST6GAL1 variants impair glucose homeostasis

    limit processed foods, choose whole grains, aim for <25g added sugars daily

Discuss with your doctor

  • type 2 diabetes risk discussion and prevention planning Moderate

    Clinical risk stratification optimizes preventive intervention intensity

Exercise

  • progressive resistance training Moderate

    Muscle training enhances insulin sensitivity and metabolic capacity

    2+ sessions per week, major muscle groups

  • regular moderate-intensity aerobic exercise Moderate

    Aerobic exercise improves insulin sensitivity and glucose clearance

    150+ minutes per week at moderate intensity

Lifestyle

  • maintain healthy body weight or achieve modest weight loss Moderate

    Excess adiposity worsens insulin resistance; modest weight loss reduces diabetes risk

    if overweight, target 5-10% weight loss

Screening

  • annual fasting glucose and hemoglobin A1c screening Moderate

    Early detection enables intervention before diabetes progression

    annual HbA1c and fasting glucose