rs113281820 - MED13L - MIR4472-2
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries - Unknown journal (n.d.) · Unknown authors · PubMed 37156999
ABSTRACT: Inflammatory bowel diseases (IBD) are chronic disorders of the gastrointestinal tract with two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most IBD genetic associations were derived from individuals of European ancestries (EUR). Here we report the largest IBD study of individuals of East Asian ancestries (EAS), including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among which 81 are novel. EAS enriched coding variants implicate many new IBD genes, including ADAP1 and GIT2. While IBD genetic effects are generally consistent across ancestries, genetics underlying CD appears more ancestry dependent than UC, driven by both allele frequency (NOD2) and effect (TN
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic Crohn's disease risk and screening strategy Moderate
Variant confers 1.19x relative risk for Crohn's disease in GWAS
Discuss risk assessment and symptom monitoring with healthcare provider
Screening
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monitor gastrointestinal symptoms for Crohn's disease Moderate
Genetic variant is associated with increased Crohn's disease susceptibility
Report persistent abdominal pain, diarrhea, or blood in stool promptly