rs113257032 - LINC02966

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association studies reveal new insights into the genetic basis of IgG4-related disease in the Chinese Han population. - Annals of the rheumatic diseases (2026) · Yan S, Peng Y, Xu J, Liu Y, Li Z, Yang Y, Peng L, Zhou J, Li L, Liu C, Chen H, Wang M, Wu Z, Zhang S, Xu H, Li H, Feng F, Fei Y, Chen Y, Dong L, Li M, Li Z, Zhang F, Zuo X, Zhang W, Li Y · PubMed 41298177

  IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder of unknown aetiology, potentially linked to genetic factors. This study conducted the first genome-wide association study on IgG4-RD in the Chinese Han population to identify genetic susceptibility loci. The study analysed data from 1161 patients with IgG4-RD and 10,539 controls across 2 independent cohorts, with 1115 patients and 10,154 controls passing quality control criteria. Using the Han-MHC reference dataset of the Chinese Han population, IgG4-RD genotyping data were imputed for the human leukocyte antigen (HLA) locus. Additionally, the study assessed the association between genetic variants and clinical characteristics, including disease activity, subtype classification, and relapse. We identified 22 si

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