Expressive

rs113255079 - PDE3B

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • vitamin D (25-OH) level Moderate

    Carriers of the T risk allele show lower vitamin D levels in large population studies, likely due to reduced expression of CYP2R1 in sun-exposed skin, which is critical for vitamin D synthesis

    Establish baseline, then test annually or semi-annually

Supplements

  • vitamin D3 supplementation Moderate

    Genetic predisposition to lower vitamin D levels; supplementation helps maintain adequate status when dietary intake is insufficient

    If tested level is below 30 ng/mL, supplement with 1000-2000 IU daily