rs113113429 - RPL34P27 - LSP1P1

Magnitude 2.0 · 1 study on file

Reported associations

• UACA locus is associated with breast cancer chemoresistance and survival - Unknown journal (n.d.) · Unknown authors · PubMed 35322040

  ABSTRACT: Few germline genetic variants have been robustly linked with breast cancer outcomes. We conducted trans-ethnic meta genome-wide association study (GWAS) of overall survival (OS) in 3973 breast cancer patients from the Pathways Study, one of the largest prospective breast cancer survivor cohorts. A locus spanning the UACA gene, a key regulator of tumor suppressor Par-4, was associated with OS in patients taking Par-4 dependent chemotherapies, including anthracyclines and anti-HER2 therapy, at a genome-wide significance level (). This association was confirmed in meta-analysis across four independent prospective breast cancer cohorts (combined hazard ratio = 1.84, ). Transcriptome-wide association study revealed higher UACA gene expression was significantly associated with worse OS

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