rs113109016 - LINC02994 - NKX6-1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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glucose metabolism risk and diabetes prevention Moderate
GWAS association with fasting glucose suggests increased metabolic risk warranting clinical review.
Discuss screening frequency for glucose and metabolic syndrome
Lifestyle
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increase physical activity for glucose control Moderate
Exercise improves insulin sensitivity and glucose utilization, mitigating genetic predisposition to dysregulation.
150 minutes per week moderate-intensity exercise
Screening
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fasting blood glucose Moderate
rs113109016 is associated with elevated fasting blood glucose levels.
Annual fasting glucose and HbA1c screening