rs113094403 - AKT3 - LINC02774
Magnitude 2.8 · 1 study on file
Reported associations
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Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits - Unknown journal (n.d.) · Unknown authors · PubMed 35121771
ABSTRACT: The expanding use of the phenome-wide association study (PheWAS) faces challenges in the context of using International Classification of Diseases billing codes for phenotype definition, imbalanced study population ethnicity, and constrained application of the results in research. We performed a PheWAS utilizing 136 deep phenotypes corroborated by comprehensive health check-ups in a Korean population, along with trans-ethnic comparisons through using the UK Biobank and Biobank Japan Project. Meta-analysis with Korean and Japanese population was done. The PheWAS associated 65 phenotypes with 14,101 significant variants (P < 4.92 × 10-10). Network analysis, visualization of cross-phenotype mapping, and causal inference mapping with Mendelian randomization were conducted.
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Lipid panel and blood pressure screening Moderate
Modifiable MI risk factors including cholesterol and hypertension require regular monitoring given increased genetic risk.
Annual lipid panel and blood pressure check; more frequent if abnormalities detected
Diet
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Heart-healthy diet low in saturated fat and sodium Moderate
Dietary modifications are standard MI prevention measures and are more important given increased genetic risk.
Limit saturated fat to less than 7% of calories; limit sodium to less than 2300 mg daily
Discuss with your doctor
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Personalized cardiovascular risk management strategy Moderate
Variant carriers have elevated myocardial infarction risk and should work with healthcare provider on targeted prevention plan.
Exercise
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Regular aerobic exercise for cardiovascular protection Moderate
Aerobic exercise is established cardioprotective measure particularly important given increased genetic MI risk.
Aim for 150 minutes of moderate-intensity aerobic exercise per week
Screening
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Cardiovascular disease screening and assessment Moderate
Genetic variant associated with 1.4-fold increased myocardial infarction risk warrants proactive screening for cardiac risk factors.
Baseline cardiovascular assessment; repeat every 2-3 years starting at age 30 (or sooner if other risk factors present)