rs113081691 - ARHGAP42
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608
ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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limit sodium intake Moderate
dietary sodium increases blood pressure; genetic predisposition to elevated blood pressure warrants conservative sodium intake
target less than 2300 mg daily, ideally less than 1500 mg daily
Discuss with your doctor
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cardiovascular risk assessment with provider Moderate
genetic association with elevated blood pressure indicates need for personalized cardiovascular risk assessment and preventive care planning
Exercise
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regular aerobic exercise Moderate
genetic predisposition to elevated blood pressure; aerobic exercise is an established intervention for blood pressure reduction
150 minutes moderate intensity or 75 minutes vigorous intensity weekly
Screening
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systolic blood pressure monitoring Moderate
rs113081691 G allele associated with elevated systolic blood pressure in genome-wide association study of 1.2 million individuals
annual measurement; more frequently if baseline elevated